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Home » Antidepressants, SNRIs

PRISTIQ® (pris-TEEK) (desvenlafaxine)

Submitted by on November 20, 2016 – 12:22 pm | 195 views

PRISTIQ® (pris-TEEK) (desvenlafaxine)

MEDICATION GUIDE Extended-Release Tablets

Read this Medication Guide before you start taking PRISTIQ and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

Antidepressant Medicines, and Other Serious Mental Illnesses, and Suicidal Thoughts or Actions

Talk to your healthcare provider about:

 all risks and benefits of treatment with antidepressant medicines

 all treatment choices for depression or other serious mental illness

What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions?

  1. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.
  2. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar illness (also called manic-depressive illness) or suicidal thoughts or actions.
  3. How can I watch for and try to prevent suicidal thoughts and actions?

 Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.

 Call the healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings.  Keep all follow-up visits with the healthcare provider as scheduled. Call the healthcare provider between visits as needed, especially if you have concerns about symptoms.

Call a healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • trouble sleeping (insomnia)
  • attempts to commit suicide
  • new or worse irritability
  • new or worse depression
  • acting aggressive, being angry, or violent
  • new or worse anxiety
  • acting on dangerous impulses
  • an extreme increase in activity and talking
  • feeling very agitated or restless (mania)
  • panic attacks
  • other unusual changes in behavior or mood

What else do I need to know about antidepressant medicines?

 Never stop an antidepressant medicine without first talking to a healthcare provider. Stopping an antidepressant medicine suddenly can cause other symptoms.

Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients should discuss all treatment choices with the healthcare provider, not just the use of antidepressants.

 Antidepressant medicines have other side effects. Talk to the healthcare provider about the side effects of this medicine.

 Antidepressant medicines can interact with other medicines. Know all of the medicines that you take. Keep a list of all medicines to show the healthcare provider. Do not start new medicines without first checking with your healthcare provider.

 Not all antidepressant medicines prescribed for children are FDA approved for use in children. Talk to your child’s healthcare provider for more information.

Important Information about PRISTIQ® Extended-Release Tablets

Read the patient information that comes with PRISTIQ before you take PRISTIQ and each time you refill your prescription. There may be new information. If you have questions, ask your healthcare provider. This information does not take the place of talking with your healthcare provider about your medical condition or treatment.

What is PRISTIQ?

  • PRISTIQ is a prescription medicine used to treat depression. PRISTIQ belongs to a class of medicines known as SNRIs (or serotonin-norepinephrine reuptake inhibitors).

Who should not take PRISTIQ?

Do not take PRISTIQ if you:

  • are allergic to desvenlafaxine, venlafaxine or any of the ingredients in PRISTIQ. See the end of this Medication Guide for a complete list of ingredients in PRISTIQ.
  • take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid and the intravenous medicine methylene blue.
  • have taken an MAOI within 7 days of stopping PRISTIQ unless directed by your healthcare provider.
  • have started PRISTIQ and if you stopped taking an MAOI in the last 14 days unless directed by your healthcare provider.

What should I tell my healthcare provider before taking PRISTIQ?

Tell your healthcare provider about all your medical conditions, including if you:

  • have
  • have
  • have high cholesterol or high triglycerides
  • have a history of a stroke
  • have or had depression, suicidal thoughts or behavior
  • have kidney problems
  • have liver problems
  • have or had bleeding problems
  • have or had seizures or convulsions
  • have mania or bipolar disorder
  • have low sodium levels in your blood
  • are pregnant or plan to become pregnant. It is not known if PRISTIQ will harm your unborn baby.
  • are breastfeeding. PRISTIQ can pass into your breast milk and may harm your baby.

Talk with your healthcare provider about the best way to feed your baby if you take PRISTIQ.

Serotonin syndrome

Rare, but potentially life-threatening conditions called serotonin syndrome can happen when medicines such as PRISTIQ are taken with certain other medicines. Serotonin syndrome can cause serious changes in how your brain, muscles, heart and blood vessels, and digestive system work. Especially tell your healthcare provider if you take the following:

 medicines to treat migraine headaches known as triptans

 medicines used to treat mood, anxiety, psychotic, or thought disorders, including , lithium, selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), or other dopamine antagonists, such as metoclopramide

 silbutramine

 St. John’s Wort

MAOIs (including linezolid, an antibiotic and intravenous methylene blue)

 tryptophan supplements

Ask your healthcare provider if you are not sure if you are taking any of these medicines.

Before you take PRISTIQ with any of these medicines, talk to your healthcare provider about serotonin syndrome. See “What are the possible side effects of PRISTIQ?”

Do not take PRISTIQ with other medicines containing venlafaxine or desvenlafaxine.

How should I take PRISTIQ?

 Take PRISTIQ exactly as your healthcare provider has told you.

 Take PRISTIQ at about the same time each day.

 PRISTIQ may be taken either with or without food.

 Swallow PRISTIQ tablets whole, with fluid. Do not crush, cut, chew, or dissolve

PRISTIQ tablets because the tablets are time-released.

 When you take PRISTIQ, you may see something in your stool that looks like a tablet. This is the empty shell from the tablet after the medicine has been absorbed by your body.

 It is common for antidepressant medicines such as PRISTIQ to take several weeks before you start to feel better. Do not stop taking PRISTIQ if you do not feel results right away.

 Do not stop taking or change the dose of PRISTIQ without talking with your healthcare provider, even if you feel better.

 Talk with your healthcare provider about how long you should use PRISTIQ. Take PRISTIQ for as long as your healthcare provider tells you to.

 If you miss a dose of PRISTIQ, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not try to “make up” for the missed dose by taking two doses at the same time.

 Do not take more PRISTIQ than prescribed by your healthcare provider. If you take more PRISTIQ than the amount prescribed, contact your healthcare provider right away.  If you take too much PRISTIQ, call the Poison Control Center at 1-800-222-1222 or go to the nearest hospital emergency room right away.

Switching from other antidepressants

Side effects from discontinuing antidepressant medication have occurred when patients switched from other antidepressants, including venlafaxine, to PRISTIQ. Your doctor may gradually reduce the dose of your initial antidepressant medication to help to reduce these side effects.

What should I avoid while taking PRISTIQ?

 Do not drive a car or operate machinery until you know how PRISTIQ affects you.  Avoid drinking alcohol while taking PRISTIQ.

What are the possible side effects of PRISTIQ?

PRISTIQ can cause serious side effects, including:

 See the beginning of this Medication Guide -Antidepressant Medicines, Depression and other Serious Mental Illnesses, and Suicidal Thoughts or Actions.

 Serotonin syndrome. See “What should I tell my healthcare provider before taking PRISTIQ?”

Get medical help right away if you think that you have these syndromes. Signs and symptoms of these syndromes may include one or more of the following:

  • restlessness
  • increase in blood pressure
  • hallucinations (seeing and hearing things
  • diarrhea that are not real)
  • loss of coordination
  • coma
  • fast heart beat
  • nausea
  • increased body temperature
  • muscle stiffness
  • confusion

PRISTIQ may also cause other serious side effects, including:

 New or worsened high blood pressure (hypertension). Your healthcare provider should monitor your blood pressure before and while you are taking PRISTIQ. If you have high blood pressure, it should be controlled before you start taking PRISTIQ.

 Abnormal bleeding or bruising. PRISTIQ and other SNRIs/SSRIs may cause you to have an increased chance of bleeding. Taking aspirin, (non-steroidal anti-inflammatory drugs), or blood thinners may add to this risk. Tell your healthcare provider right away about any unusual bleeding or bruising.

 Visual problems

 eye pain

 swelling or redness in or around the eye

Only some people are at risk for these problems. You may want to undergo an eye

examination to see if you are at risk and receive preventative treatment if you are.

Symptoms when stopping PRISTIQ (discontinuation symptoms). Side effects may occur when stopping PRISTIQ (discontinuation symptoms), especially when therapy is stopped suddenly. Your healthcare provider may want to decrease your dose slowly to help avoid side effects. Some of these side effects may include:

  • dizziness
  • anxiety
  • nausea
  • abnormal dreams
  • headache
  • tiredness
  • irritability
  • sweating
  • (insomnia)
  • diarrhea
  • Seizures (convulsions)
  • Low sodium levels in your blood. Symptoms of this may include: headache, difficulty concentrating, memory changes, confusion, weakness and unsteadiness on your feet. In severe or more sudden cases, symptoms can include: hallucinations (seeing or hearing things that are not real), fainting, seizures and coma. If not treated, severe low sodium levels could be fatal.
  • Lung problems. Some people who have taken the medicine venlafaxine which is the same kind of medicine as the medicine in PRISTIQ have had lung problems. Symptoms of lung problems include difficulty breathing, cough, or chest discomfort. Tell your healthcare provider right away if you have any of these symptoms.

Common side effects with PRISTIQ include:

  • nausea
  • sleepiness
  • dizziness
  • loss of appetite
  • insomnia
  • anxiety
  • sweating
  • decreased sex drive
  • constipation
  • delayed orgasm and ejaculation

These are not all the possible side effects of PRISTIQ. Tell your healthcare provider about any side effect that bothers you or does not go away.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store PRISTIQ?

 Store PRISTIQ at 68°F to 77°F (20°C to 25°C).

 Do not use PRISTIQ after the expiration date (EXP), which is on the container. The expiration date refers to the last day of that month.

 Keep PRISTIQ and all medicines out of the reach of children.

General Information about the safe and effective use of PRISTIQ

Medicines are sometimes used for conditions that are not mentioned in Medication Guides. Do not use PRISTIQ for a condition for which it was not prescribed. Do not give PRISTIQ to other people, even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about PRISTIQ. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about PRISTIQ that is written for healthcare professionals.

For more information, go to www.pristiq.com or call 1-888-PRISTIQ (774-7847).

What are the ingredients in PRISTIQ?

Active ingredient: desvenlafaxine

Inactive ingredients: For the 50 mg tablet, hypromellose, microcrystalline cellulose, talc, and film coating, which consists of , polyethylene glycol, talc, titanium dioxide, and iron oxides.

For the 100 mg tablet, hypromellose, microcrystalline cellulose, talc, magnesium stearate, a film coating which consists of polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, iron oxide and FD&C yellow #6.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

LAB-0539-6.0 Revised July 2014

Reference ID: 3593957

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