VALIUM® ROCHE® (diazepam)
Tablets 5 mg, 10 mg
THERAPEUTIC CLASSIFICATION
Anxiolytic-sedative
ACTIONS AND CLINICAL PHARMACOLOGY
‘Valium’ (diazepam) is an anxiolytic-sedative drug useful in the symptomatic relief of anxiety and tension states. It has also adjunctive value in the relief of certain neurospastic conditions.
ABSORPTION:
Diazepam is rapidly and completely absorbed from the gastrointestinal tract, peak plasma concentrations appearing 30-90 minutes after oral ingestion.
DISTRIBUTION:
Diazepam and its metabolites are highly bound to plasma proteins (diazepam 98%). The volume of distribution at steady state is 0.8-1.0 L/kg. In humans, comparable blood levels of ‘Valium’ were obtained in maternal and …

SSRI discontinuation syndrome

When was the SSRI discontinuation syndrome first recognized?
Reports began to emerge soon after the SSRIs were introduced in the late 1980s.
How common is it? The incidence and prevalence of this syndrome is not yet known. The few available discontinuation studies indicate minor forms of the syndrome may be common and severe forms unusual. A retrospective chart review of 171 clinic patients who discontinued an SSRI while under supervision, reported at least one new symptom in 20% and 14% of patients stopping paroxetine (Paxil) and fluvoxamine (Luvox), …

TEGRETOL Novartis
Carbamazepine
Use:
Anticonvulsant, antimanic agent. Epilepsy: Adults and children > 12 years – initially, 100-200 mg once or twice a day; increased in divided doses until best response obtained. Optimal daily dosage: 800-1200 mg. Rarely, some adults may require 1600 mg/day. As soon as disappearance of seizures has been obtained and maintained, reduce dosage very gradually to minimum effective dose. Children 6-12 years: Initially, 100 mg in divided doses on first day; increased by 100mg/day until best response obtained. Maximum daily dosage: 1000mg.
Trigeminal neuralgia: Initially, 100 mg twice daily; increased …