Selective serotonin reuptake inhibitors
Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants considered the current standard of drug treatment. A possible cause of depression is an inadequate amount of serotonin, a chemical used in the brain to transmit signals between neurons. SSRIs are said to work by preventing the reuptake of serotonin (also known as 5-hydroxytryptamine, or 5-HT) by the presynaptic neuron, thus maintaining higher levels of 5-HT in the synapse. Chemists Klaus Schmiegel and Bryan Molloy of Eli Lilly discovered the first SSRI, fluoxetine. This class of …

Sertraline
Sertraline hydrochloride (trade names Zoloft and Lustral) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily used to treat major depression in adult outpatients as well as obsessive–compulsive, panic, and social anxiety disorders in both adults and children. In 2007, it was the most prescribed antidepressant on the U.S. retail market, with 29,652,000 prescriptions.
The efficacy of sertraline for depression is similar to that of older tricyclic antidepressants, but its side effects are much less …

Discontinuing Antidepressants – what you need to know
Are antidepressants addictive?
Antidepressants do not cause an addiction as with opioid drugs (such as heroin), barbiturates, amphetamines (speed), alcohol and nicotine. This means that taking your medicine regularly should not cause tolerance or craving.
• Tolerance: This occurs when the body gets used to the drug or medicine when it is taken regularly, so that you need to take higher doses to have the same effect.
• Craving: This is a physical urge, where the body needs the drug or medicine to maintain a desired …

When Xanax hit the U.S. market in 1981, it wasn’t clear it would be a hit. It was a me-too successor to Valium, the anxiety drug that was the most popular drug in America for most of the 1970s. Maker Upjohn figured out a clever way to market its drug: by testing it to treat panic attacks as well as anxiety.
Panic attacks had just been defined as a diagnosis and were assumed to be resistant to Valium-like drugs. But Upjohn ran studies showing Xanax reduced panic attacks; it was the …

LUSTRAL
How does it work?
Lustral tablets contain the active ingredient sertraline hydrochloride, which is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). (NB. Sertraline tablets are also available without a brand name, ie as the generic medicine.)
Antidepressant medicines act on nerve cells in the brain. In the brain there are numerous different chemical compounds called neurotransmitters. These act as chemical messengers between the nerve cells. Serotonin is one such neurotransmitter and has various functions that we know of.
When serotonin is released from nerve cells in the …