Selective serotonin reuptake inhibitors
Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants considered the current standard of drug treatment. A possible cause of depression is an inadequate amount of serotonin, a chemical used in the brain to transmit signals between neurons. SSRIs are said to work by preventing the reuptake of serotonin (also known as 5-hydroxytryptamine, or 5-HT) by the presynaptic neuron, thus maintaining higher levels of 5-HT in the synapse. Chemists Klaus Schmiegel and Bryan Molloy of Eli Lilly discovered the first SSRI, fluoxetine. This class of …

When Xanax hit the U.S. market in 1981, it wasn’t clear it would be a hit. It was a me-too successor to Valium, the anxiety drug that was the most popular drug in America for most of the 1970s. Maker Upjohn figured out a clever way to market its drug: by testing it to treat panic attacks as well as anxiety.
Panic attacks had just been defined as a diagnosis and were assumed to be resistant to Valium-like drugs. But Upjohn ran studies showing Xanax reduced panic attacks; it was …

Prozac: PANACEA OR PANDORA?, by Ann Blake Tracy, Ph.D.
Prozac: PANACEA OR PANDORA?, by Ann Blake Tracy, Ph.D., is the product of five years of research, and the study of the cases of approximately 1,000 patients on a long-term basis. The author holds a Doctorate in Biological Psychology, and heads the only support group in the state of Utah for those who have suffered adverse reactions to the SSRI drugs such as prozac, paxil, zoloft, luvox, effexor, serzone, anafranil & the diet pills – fenfluramine, fen-phen & redux.
“Brain wave patterns indicate …

Suicide Warnings Raise Bigger Fears On Testing Process
Warnings that drugs such as Prozac, Paxil and Effexor can increase suicidal behavior in some children have resulted in a nearly 20 percent drop in U.S. pediatric prescriptions of the widely used antidepressants and have triggered deep concerns about the quality of current data on psychiatric drugs, doctors and regulators said.
The unprecedented fall of what were once considered wonder drugs comes as a series of taxpayer-funded analyses have systematically undermined the claims of industry-funded drug trials, raising thorny questions about the ways in …

Popular antidepressants including Prozac and Paxil have little impact on most patients, according to a comprehensive review of newly released data from trials that were conducted before the drugs were approved in the U.S.
Researchers from the U.K., U.S. and Canada analyzed results for fluoxetine (better known by the brand name Prozac), venlafaxine (Effexor), nefazodone (Serzone) and paroxetine (Paxil or Seroxat) — all members of a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). The researchers’ paper, published this week in the journal PLoS Medicine, claims that only patients …